Crystal Palace v Tottenham Hotspur – Saturday (12.30pm)
Patrick Vieira’s Eagles showed their fighting spirit ahead of the international break, as they twice came from a goal behind to secure a 2-2 draw against high-flying West Ham United.
Palace will need to demonstrate similar resolve if they are to end Tottenham’s 100% record – and three clean sheets from three – under new boss Nuno Espirito Santo.
With Harry Kane returning from England duty, where he scored in all three World Cup qualifiers, expect Spurs to come out on top in this London derby.
Arsenal vs Norwich City – Saturday (3pm)
The top flight’s basement boys face off at the Emirates, when Norwich travel to Arsenal.
Both sides are winless, and Mikel Arteta’s men are yet to even score this season.
The Gunners will be hoping recent history is on their side, having lost just two of their 18 Premier League meetings with Norwich (W9 D7), as a defeat would condemn them to their worst start since 1923-24.
Brentford v Brighton – Saturday (3pm)
Brentford go into this first ever top-flight meeting with Brighton full of confidence, having avoided defeat in 18 of their previous 19 games in all competitions.
Thomas Frank’s men are looking to become the first Premier League debutants to go their opening four matches unbeaten since Portsmouth in 2003-04.
The Seagulls have also started the season well with six points to their name, but have a poor record in the capital – recording just three wins in their 22 London matches (D8 L11) since promotion to the Premier League.
Leicester City v Manchester City – Saturday (3pm)
Leicester City will be looking to make it two wins from two against the Premier League champions this season, following the Foxes’ Community Shield victory over the Citizens in August.
Manchester City, meanwhile, are targeting their third straight Premier League victory – after winning both of their two previous matches 5-0.
Leicester have also picked up six points from their first three games, with wins over Wolverhampton Wanderers and Norwich City sandwiching a chastening 4-1 defeat at West Ham United.
Manchester United v Newcastle United – Saturday (3pm)
You might have heard that Cristiano Ronaldo is back.
CR7 looks set to make his second debut against a side who have had a typically poor start to the season – and he has a superb record against the Magpies.
With six goals and five assists in his 11 appearances vs Newcastle (W10 D1), Steve Bruce’s outfit could well be just a sideshow in this encounter.
Southampton v West Ham United – Saturday (3pm)
West Ham United will be seeking to maintain their three-match unbeaten run when they travel to the South Coast on Saturday.
They will face a Southampton side who are still waiting to pick up their first victory of the season.
Ralph Hasenhuttl’s men looked to be down and out on their last outing against Newcastle United, but a 96th-minute James Ward-Prowse equaliser salvaged a point for the Saints.
Their defence will face a tougher test this weekend, with the division’s leading goalscorer Michail Antonio in the Hammers’ ranks – he became the first ever player to score 50 Premier League goals for the East Londoners last time out.
Watford v Wolverhampton Wanderers – Saturday (3pm)
Watford host pointless Wolverhampton Wanderers on Saturday afternoon, with both sides looking to kick-start their season following the international break.
The Hornets have the third-lowest expected goals (xG) tally in the league so far, averaging a mere 0.87 per 90 minutes played.
Wolves, in contrast, are a more than respectable seventh in the xG rankings with 1.43 per 90, despite being yet to score a goal.
Chelsea v Aston Villa – Saturday (5.30pm)
European champions Chelsea have made an unbeaten start to the season, but Aston Villa will be aiming to end that run when they visit Stamford Bridge.
Thomas Tuchel’s side have picked straight up from where they left off last season, beating London rivals Crystal Palace and Arsenal in the first two gameweeks.
The Blues were then held to a 1-1 draw against Liverpool, despite only having ten men for the entire second half.
Aston Villa will be relying on star striker Danny Ings to help them secure a result – he now has two goals in three league appearances for the Villans.
Leeds United v Liverpool – Sunday (4pm)
Leeds United are going in search of their first win this season – but they will have to overcome unbeaten Liverpool first.
Jurgen Klopp’s men are undefeated in their last 10 matches against Leeds in all competitions, winning one of last term’s encounters (4-3) and drawing the other (1-1).
Leeds, meanwhile, haven’t lost any of their last seven Premier League home matches, and have scored at least twice in each of their previous three.
Everton v Burnley – Monday (8pm)
The 2021-22 campaign has seen Everton and Burnley experience contrasting fortunes – the Toffees are unbeaten, while the Clarets only have a single point on the board.
Carlo Ancelotti’s Everton have scored at least two goals in their last three Premier League matches, but could be without talisman Dominic Calvert-Lewin, who pulled out of the England squad with a quad injury.
Visitors Burnley have failed to win their last six Premier League matches, after being held to a 1-1 draw at home to Leeds last time out.