Newcastle United vs Leeds United - Friday, 8pm
With just one point from their opening four matches, the pressure is once again starting to ramp up on Steve Bruce.
Looking to take advantage of that will be Marcelo Bielsa’s Leeds, who are yet to start firing on all cylinders themselves.
If the Whites can get an early goal, expect the St. James’ Park faithful to grow increasingly frustrated at the current state of affairs – something Leeds could take full advantage of.
Wolverhampton Wanderers vs Brentford - Saturday, 12:30pm
Both sides come into this one on the back of firsts for the season.
Wolves will be looking to build upon their opening win of the campaign, whilst the Bees are aiming to bounce back from a first defeat.
The hosts have a good recent record against the West Londoners, having won three and drawn one of their last four league meetings – most recently winning 3-0 at Molineux back in January 2018.
Burnley vs Arsenal - Saturday, 3pm
Clarets boss Sean Dyche isn’t going to be getting many Christmas cards from his peers this December.
Not one game has gone by without the opposition bemoaning Burnley’s players and their industrious challenges.
Visitors Arsenal are heading to one of their happier hunting grounds, having not lost a league game at Turf Moor since December 1973.
With confidence growing after last weekend's win, plus no midweek European distractions, the Gunners will be aiming to haul themselves further clear of the relegation places.
Liverpool vs Crystal Palace - Saturday, 3pm
Anfield was rocking on Wednesday night, as the Reds came out on top of a 3-2 thriller in the Champions League against AC Milan.
Patrick Vieira – a former Rossoneri player himself – is next in line to face Jurgen Klopp’s side, with his Palace team full of confidence after dismantling Tottenham last weekend.
The odds will be stacked against the South Londoners again this afternoon, having lost their last eight Premier League encounters with the Reds – conceding 24 goals in the process and scoring just five.
Manchester City vs Southampton - Saturday, 3pm
The Citizens’ last three home matches in all competitions have seen them amass 16 goals, six of which came in the Champions League on Wednesday.
Next to bravely enter Pep’s coliseum is Ralph Hasenhuttl’s Saints – a side famous for shipping plenty of goals when things start to go awry.
It was a 5-2 defeat in this fixture last season, and it wouldn’t be surprising to see a scoreline this time around given Manchester City’s current form.
Norwich City vs Watford - Saturday, 3pm
Last season’s Championship top two meet once again at Carrow Road, with the Hornets looking for revenge after the Canaries pipped them to the title in 2020-21.
Despite missing out on top spot, it is the Hertfordshire outfit who have the better recent record against their Norfolk-based opponents, having won each of their last four league meetings – including two 1-0 victories last term.
Norwich will be looking to do all they can to lift themselves off the bottom of the table, as Daniel Farke’s winless side bid to put last week’s disappointing 1-0 loss to fellow strugglers Arsenal behind them.
Aston Villa vs Everton - Saturday, 5:30pm
Rafa Bentitez has enjoyed the near-perfect start he needed to get Everton’s fans onside, following his controversial appointment.
The Toffees were unbeaten in their first five league games last term, but have never achieved that feat in consecutive campaigns – so will be looking to break new ground at Villa Park.
The Villans are yet to fully convince following Jack Grealish’s departure, but in Danny Ings they have a man who loves to score against Saturday’s opponents.
His five goals against the Toffees is the most he has managed against any top flight club.
Brighton & Hove Albion vs Leicester City - Sunday, 2pm
Graham Potter’s Brighton have been the surprise package of the season’s opening rounds and currently occupy sixth place, after three wins and one defeat.
The Seagulls welcome a Leicester side who they have never beaten in the Premier League, with the Foxes coming out on top six times, plus a further two draws.
Jamie Vardy is a man who is rarely quiet in most games, but against Brighton he is particularly potent – scoring five goals and contributing three assists.
West Ham United vs Manchester United - Sunday, 2pm
The Red Devils came back down to earth with a bump on Tuesday night, after a late defeat to Swiss side Young Boys in the Champions League.
Ole Gunnar Solskjaer’s men will have their mental resolve tested, as they look to extend their league record of 28 away matches unbeaten when they head to East London.
Michail Antonio’s suspension has made David Moyes’ task against his former employers an even tougher one, with the Hammers winning just 28% of matches when he doesn’t start, compared to 41% when he does.
It will also be the first time they play on the back of European exploits, returning to the capital from Zagreb in the early hours of Friday morning.
Tottenham Hotspur vs Chelsea - Sunday, 4:30pm
Sunday concludes with the weekend’s standout fixture between Tottenham and Chelsea.
This tie has become a real grudge match in recent years, and it will be the first big London derby to have supporters back in the stands.
Spurs fans will be going into this one tentatively, with an injury depleted squad looking to stop the Blues from winning a third successive match on their turf.
Thomas Tuchel will be aiming for another clean sheet, as his side have managed in 61% of the league games he has been in charge.
It’s the best clean sheet ratio of any manager (with a minimum of 10 games) at one club in the competition’s history.