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With many of the big names already gone from this tournament, and with Champions League qualification via a top-four spot increasingly likely, Ole Gunnar Solskjaer will be picking something akin to his strongest side here in search of that first bit of elusive silverware.
He will have to make do without Anthony Martial, Eric Bailly and Phil Jones, while Marcus Rashford, Alex Telles and Juan Mata are doubts, though arguably the England striker is the only one of those who would command a spot in the starting line-up when everyone is available.
Rashford is not yet ruled out, but having taken a knock, may have to settle for a place on the bench if passed fit for action.
Granada arguably have greater concerns, with a string of players missing for this tie. In particular, head coach Diego Martinez has a problem at full-back, where first-choice duo Carlos Neva and Dimitri Foulquier are unlikely to feature, while Quini (who can fill in on either flank) is ineligible to feature in this tournament. Midfielder Luis Milla and striker Luis Suarez are the other major absentees, so veteran Roberto Soldado should lead the line.
Granada head into this fixture off the back of three consecutive defeats, losing 3-0 at home to Villarreal last time out as they sank to ninth in the table domestically.
In fact, excluding a Copa del Rey meeting with third-tier outfit Navalcarnero, Granada are just W4-D4-L8 since mid-January. However, despite that form, they have proven adept at registering on the scoreboard, failing to score in just two of those games in total.
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Man United To Win 1-0, 2-0, 2-1 Multibet
That doesn’t necessarily mean that they’ll be able to net here though. United may have failed to keep clean sheets in their last two outings, but prior to that they’d conceded just one goal in seven appearances, shutting out the likes of Real Sociedad, Chelsea, Man City, West Ham and Milan in the second leg of their Last 16 tie in Italy.
The Red Devils recovered from their 3-1 FA Cup defeat versus Leicester to win 2-1 at Brighton last time out. That result against the Foxes remains their sole loss in 16 appearances since late January, though they did draw eight of these.
However, at least six of those stalemates came against teams better than their opponents here (Arsenal, Everton, West Ham, Real Sociedad, Chelsea and Milan).
United are W16-D9-L2 in the Europa League since December 2016 and W9-D5-L2 under Ole Gunnar Solskjaer in this competition.
Having conceded just once across their four knockout games against Real Sociedad and Milan, the expectation will be that they’ll register another clean sheet here.
However, Granada’s offensive record leaves the win to nil unappetizing, with four of their past five defeats seeing them go down 2-1.
They shouldn’t get too many chances though and as they seek to deny Man Utd opportunities to rack up the away goals, the multibet angle looks a profitable one.