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United took a comfortable 2-0 win in the first leg and will be expected to get the job done at Old Trafford.
Their weekend win over Tottenham also puts them in a commanding position domestically, with third-placed Leicester losing at the weekend to fall seven points adrift, so Ole Gunnar Solskjaer can afford to concentrate solely on this competition with silverware a must for this campaign to be considered successful.
The Norwegian does however have a number of absentees for this clash. Luke Shaw, Harry Maguire and Scott McTominay are all suspended, while Anthony Martial and Phil Jones are absent through injury.
Eric Bailly is also unlikely to feature having spent almost a month away in quarantine, so there should be opportunities for some fringe players to impress.
Still, United have lost just once in 18 appearances, winning five of the last six, which includes victories over the likes of West Ham, Milan and Tottenham.
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That would suggest there’ll be no slip-up here, and Granada’s recent form would make such an event even more unlikely.
The Spanish outfit did manage to finally win a game for the first time in a month this weekend, away at relegation-battling Real Valladolid, though they’d lost four on the bounce prior to that and it’s difficult to see them overturning the first-leg result.
Granada did however come close to scoring on home turf as Yangel Herrera hit the woodwork, while former Chelsea winger Kenedy tried his luck a few times from distance.
Granada actually boast a fairly healthy scoring record, failing to register in just three of their past 21 appearances, and with United missing a few defenders, could come away with a goal.
In fact, Granada have scored in six of seven away matches in Europe this term, and although for the most part they haven’t faced too many quality outfits, this still includes a pair of goals away at PSV in the group stages and strikes in 2-1 defeats to both Napoli and Molde in the knockout rounds.
Overall, a similar performance from the first leg should be expected here. We wouldn’t completely trust the hosts to keep a clean sheet with a few defenders missing and with Granada capable going forwards, but there is a clear gulf in quality between the two sides that is hard to ignore.
Given United’s 3-1 win over Tottenham this weekend was the first time in 11 appearances where they’d scored more than twice, the multibet option appears to cover all the likely angles.